Browsing by Author "WILLIAMS, DAVID CLIVE"
Now showing items 1-5 of 5
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Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
LAWLER, MARK; WILLIAMS, DAVID CLIVE; NATHWANI, SEEMA; MEEGAN, MARY JANE; ZISTERER, DANIELA MARIA (Springer, 2010)Advanced hormone-refractory prostate cancer is associated with poor prognosis and limited treatment options. Members of the pyrrolo-1,5-benzoxazepine (PBOX) family of compounds exhibit anti-cancer properties in cancer cell ... -
Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
MEEGAN, MARY JANE; ZISTERER, DANIELA MARIA; WILLIAMS, DAVID CLIVE; KNOX, ANDREW; LLOYD, DAVID G; O'BOYLE, NIAMH (Elsevier, 2011)Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical ... -
Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo
ZISTERER, DANIELA MARIA; WILLIAMS, DAVID CLIVE; MC ELLIGOTT, TONY (Nature, 2010)Background: Imatinib is a direct and potent inhibitor of the constitutively active tyrosine kinase, breakpoint cluster region-Abelson (Bcr-Abl), which is central to the pathogenesis of chronic myeloid leukaemia (CML) ... -
Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulphur substituted a-alkylthioamphetamines
WILLIAMS, DAVID CLIVE; KAVANAGH, PIERCE VALENTINE; CLOONAN, SUZANNE; MEEGAN, MARY JANE; O'BRIEN, JOHN EUGENE; CORRIGAN, DESMOND (2010)4-Methylthioamphetamine (4-MTA) is recognised as a 3,4-methylenedioxymethamphetamine (MDMA)-like drug of abuse. Such amphetamine-type drugs often contain byproducts of uncontrolled, illegal clandestine synthetic processes. ... -
Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.
KELLY, JOHN MOFFAT; WILLIAMS, DAVID CLIVE; GUNNLAUGSSON, THORFINNUR (2013)The bi-functional complex [PtII(terpy)(py-naphth)](NO 3)2(1), incorporating both 2,2?:6?, 2??-terpyridine and 4-N,N?-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying ...