Browsing by Author "WINDLE, HENRY"
Now showing items 1-9 of 9
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Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells
KELLEHER, DERMOT P; SABRA, KAMAL; WINDLE, HENRY (Nature, 2005)Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives (honeybee resin), has anti-inflammatory, anti-carcinogenic and anti-bacterial properties. This study was designed to investigate the ... -
Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori. An aldehyde dismutating enzyme
KELLEHER, DERMOT P; TIPTON, KEITH; WINDLE, HENRY (John Wiley, 2005)Cinnamyl alcohol dehydrogenases (CAD; 1.1.1.195) catalyse the reversible conversion of p-hydroxycinnamaldehydes to their corresponding alcohols, leading to the biosynthesis of lignin in plants. Outside of plants their role ... -
A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors
WINDLE, HENRY; GILMER, JOHN FRANCIS; KELLEHER, DERMOT P; KEOGH, BRIAN; REILLY, MARY (2011)The design, synthesis and delivery potential of a new type of benzenesulfonamide cyclo-oxygenase-2 (COX-2) inhibitor prodrug is investigated using celecoxib. The approach involves a double prodrug that is activated first ... -
First detected Helicobacter pylori infection in infancy modifies the association between diarrheal disease and childhood growth in Peru
WINDLE, HENRY (2014)BACKGROUND: In endemic settings, Helicobacter pylori infection can occur shortly after birth and may be associated with a reduction in childhood growth. MATERIALS AND METHODS: This study investigated what factors ... -
Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study
WINDLE, HENRY; KELLEHER, DERMOT P (2013)Objective: Iron deficiency (ID) and iron deficiency anaemia (IDA) are global major public health problems, particularly in developing countries. Whilst an association between H. pylori infection and ID/IDA has been ... -
Multiple norovirus infections in a birth cohort in a Peruvian peri-urban community.
WINDLE, HENRY (2014)Human noroviruses are among the most common enteropathogens globally, and are a leading cause of infant diarrhea in developing countries. However, data measuring the impact of norovirus at the community level are ... -
NF-kappaB Activation in Esophageal Adenocarcinoma: Relationship to Barrett's Metaplasia, Survival, and Response to Neoadjuvant Chemoradiotherapy
KELLEHER, DERMOT P; WINDLE, HENRY (Lippincott Williams & Wilkins, 2004)OBJECTIVE: To examine the expression of the transcription factor nuclear factor kappa B (NF-kappaB) in Barrett's epithelium and adenocarcinoma and the impact of NF-kappaB expression on tumor stage and response to neoadjuvant ... -
Soluble extracts from Helicobacter pylori induce dome formation in polarized intestinal epithelial monolayers in a laminin-dependent manner
KELLEHER, DERMOT P; WINDLE, HENRY (American Society for Microbiology, 2003)Helicobacter pylori colonizes the stomach at the interface between the mucus layer and the apical pole of gastric epithelial cells. A number of secreted and shed products from the bacteria, such as proteins and lipopolysaccharide, ... -
Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages
WINDLE, HENRY; KELLEHER, DERMOT (2014)Clostridium difficile is the leading cause of hospital-acquired diarrhoea worldwide, and if the bacterium is not cleared effectively it can pose a risk of recurrent infections and complications such as colitis, sepsis and ...