Browsing by Author "Walsh, Patrick"
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Advancing the therapeutic potential of the IL-1 family in inflammatory diseases - Meeting report
Walsh, Patrick (2019)On October 9th 2018 the Trinity College Dublin hosted a workshop forum at the Royal Irish Academy to discuss recent discoveries and current areas of focus in the field of IL‐1 family biology. The aim of this meeting was ... -
Current perspectives on the interleukin-1 family as targets for inflammatory disease.
Walsh, Patrick; Lucitt, Margaret (2019)Since the first description of interleukin-1 (IL-1) and the genesis of the field of cytokine biology, the understanding of how IL-1 and related cytokines play central orchestrat- ing roles in the inflammatory response has ... -
Cytosolic dsRNA improves neonatal innate immune responses to adjuvants in use in paediatric vaccines.
Walsh, Patrick; Doyle, Sarah; Brennan, Kiva (2022)Pattern recognition receptors (PRRs) of the innate immune system represent the critical front-line defense against pathogens, and new vaccine formulations target these PRR pathways to boost vaccine responses, through ... -
Deeds and Sasines Working Paper 1: Registry of Deeds Typologies
Walsh, Patrick (2022) -
Draft Trinity Colonial Legacies Working Paper on TCD and Slavery
Walsh, Patrick; O'Neill, Ciaran (2023)In April 2023 the Board of Trinity College Dublin voted to de-name the Berkeley Library. Built in 1967 as the New Library and named after the Irish Philosopher, cleric, and Trinity alumnus, Bishop George Berkeley in 1978, ... -
Human β-Defensin 3 and Its Mouse Ortholog Murine β-Defensin 14 Activate Langerhans Cells and Exacerbate Psoriasis-Like Skin Inflammation in Mice
Walsh, Patrick; Tobin, Anne-Marie (2016) -
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells.
Walsh, Patrick; Long, Aideen; Fallon, Padraic (2022)IL-36 cytokines are emerging as potent orchestrators of intestinal inflammation and are being implicated in the pathogenesis of inflammatory bowel diseases (IBD). However, the mechanisms through which these cytokines mediate ... -
Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction.
Walsh, Patrick; Doyle, Sarah; Fallon, Padraic (2019)Members of the interleukin-1 (IL-1) family are important mediators of obesity and metabolic disease and have been described to often play opposing roles. Here we report that the interleukin-36 (IL-36) subfamily can play a ... -
Introduction to the Memorials and Transcription Books in the Registry of Deeds
Walsh, Patrick (Property Registration Authority, 2022) -
Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
Walsh, Patrick; Lavelle, Edward; Munoz-Wolf, Natalia; Martin, Seamus (2022)Interleukin-1 (IL-1) family cytokines are key barrier cytokines that are typically expressed as inactive, or partially active, precursors that require proteolysis within their amino termini for activation. IL-37 is an ... -
Parliament, power and patronage, the career of Speaker William Conolly, 1662-1729
Walsh, Patrick (Trinity College Dublin, 2007-06-13)The aim of this project is not to write a biography of Conolly but rather to examine particular facets of his career. His political career has previously been outlined in the political histories of the period and does not ... -
Patterns of Taxation in Eighteenth-Century Ireland
Walsh, Patrick (Palgrave MacMillan, 2019) -
PTEN regulates IL-2 receptor responsiveness of CD4+CD25+ regulatory T cells.
Walsh, Patrick (2006)One of the greatest barriers against harnessing the potential of CD4+CD25+ Tregs as a cellular immunotherapy is their hypoproliferative phenotype. We have previously shown that the hypoproliferative response of Tregs ... -
Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β
Fallon, Padraic; O'Neill, Luke; Walsh, Patrick; Schwartz, Christian; Moran, Tara; Saunders, Sean; Kaszlikowska, Agnieszka; Floudas, Achilleas; Bom, Joana; Nunez, Gabriel; Iwakura, Yoichiro; Irvine, Alan; McKenzie, Andrew; Ogg, Graham; Demengeot, Jocelyne (2019)Background: Atopic dermatitis (AD) is one of the most common skin diseases with a multifactorial etiology. Mutations leading to loss of skin barrier function are associated with the development of AD with group 2 innate ... -
Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by ?? T Cells.
Walsh, Patrick; Fallon, Padraic (2013)Expression of the orphan receptor Toll IL-1R8/single Ig IL-1–related receptor has been reported to be reduced in the peripheral blood of psoriatic arthritis patients. However whether TIR8/SIGIRR activity plays a specific ... -
UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation
Porter, Richard; Walsh, Patrick; Mills, Kingston; Lavelle, Edward; Munoz-Wolf, Natalia (2020)Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix from the intermembrane space. We have previously reported UCP3 ... -
Working Paper on George Berkeley's Legacies at Trinity
Walsh, Patrick; O'Neill, Ciaran (2023)This Working Paper details the memorialisation of Bishop George Berkeley (1685-1753) at Trinity College Dublin. It begins by first explaining who George Berkeley was, before moving on to discuss how he has been memorialised ...