Browsing by Subject "Amorphous"
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Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating
(2018)Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the ... -
Reducing mechanical activation-induced amorphisation of salbutamol sulphate by co-processing with selected carboxylic acids
(2013)The unintentional generation of amorphous character in crystalline active pharmaceutical ingredients (APIs) is an adverse consequence of mechanical activation during dosage form manufacture. In this study, we assess and ... -
Solubility of crystalline organic compounds in high and low molecular weight amorphous matrices above and below the glass transition by zero enthalpy extrapolation
(2014)Pharmaceutical applications which require knowledge of the solubility of a crystalline compound in an amorphous matrix are abundant in the literature. Several methods that allow the determination of such data have been ...