Browsing by Subject "Amyotrophic Lateral Sclerosis"
Now showing items 1-7 of 7
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Genetic Epidemiology and Cognitive Endophenotyping in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Amyotrophic Lateral Sclerosis (ALS) is a progressive debilitating and ultimately fatal neurodegenerative disorder affecting both upper (UMN) and lower (LMN) motor neurons. While it has been long known to exist on a spectrum ... -
Human Neurodegeneration: A Spectral EEG and TMS based Approach in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Amyotrophic lateral sclerosis (ALS) is defined by the neurodegeneration of upper and lower motor neurons of the corticospinal tract, resulting in progressive, terminal and incurable decline in movement, speech and swallowing ... -
A Longitudinal Study of the Complex Needs of Motor Neuron Disease Caregivers
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Motor Neuron Disease (MND) is the term used to describe a number of terminal incurable neurodegenerative disorders, of which Amyotrophic Lateral Sclerosis (ALS) is the most common type. MND is characterised by the progressive ... -
Measuring physical function in Amyotrophic Lateral Sclerosis: Novel solutions to an old problem
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)Sensitive, objective outcome measures are essential for tracking clinical severity in neurodegenerative conditions such as Amyotrophic Lateral Sclerosis or Parkinson’s Disease. The current ‘gold standard’ multi-item rating ... -
Motor and extra-motor involvement in amyotrophic lateral sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Amyotrophic Lateral Sclerosis (ALS) is primarily associated with pathology in the motor cortex and corticospinal tract. Based on clinical observations, it is increasingly recognised that extra-motor symptoms add to the ... -
Network Analysis in Amyotrophic Lateral Sclerosis during Voluntary Motor Task: Neurophysiological Biomarkers of Disrupted Cortical Connections
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that causes degeneration of both upper and lower motor neurons primarily affecting the motor system, but individual people with ALS show ... -
Neuropsychological and Neuropsychiatric Endophenotypes in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive muscle weakness and death, usually within 3-5 years from symptom onset. ALS is now recognized to be a multi-system ...