Browsing by Subject "Amyotrophic lateral sclerosis"
Now showing items 1-5 of 5
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Characterising the effects of sex interaction, pleiotropy and local population structure on ALS GWAS
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)In the past decade, increasingly large-scale genome wide association studies (GWAS) have gleaned insights into the genetic architecture of a range of human traits. Widespread sharing of summary statistics for these GWAS ... -
The clinical and neuroimaging profiles of primary lateral sclerosis: a longitudinal research study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Primary Lateral Sclerosis (PLS) is a progressive, idiopathic upper motor neuron (UMN) disease. Clinically, PLS is defined by the presence of spasticity and associated UMN signs without concurrent evidence of lower motor ... -
Genetic heterogeneity in amyotrophic lateral sclerosis and related disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The overarching aim of this thesis is to clarify and further our understanding of the genetic causes of amyotrophic lateral sclerosis (ALS) and related diseases. It is hoped that achieving this can help bring clarity to ... -
Lessons of ALS imaging: Pitfalls and future directions - A critical review
(2014)Background: While neuroimaging in ALS has gained unprecedented momentum in recent years, little progress has been made in the development of viable diagnostic, prognostic and monitoring markers. Objectives: To identify ... -
Use of Pharyngeal High-Resolution Manometry to Evaluate Dysphagia in Adults with Motor Neurone Disease: A Scoping Review
(2022)There has been a recent shift towards proactive dysphagia intervention in motor neurone disease (MND) to maintain physiological reserve. Pharyngeal high-resolution manometry (PHRM) can quantify swallowing pathophysiology ...