Browsing by Subject "Astrocytes"
Now showing items 1-12 of 12
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Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms
(BMC, 2017)Amyotrophic lateral sclerosis, a devastating neurodegenerative disease, is characterized by the progressive loss of motor neurons and the accumulation of misfolded protein aggregates. The latter suggests impaired proteostasis ... -
Antipsychotics Prevent Psychosine Induced Toxicity in Glial Cells.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glial cells are implicated in the neuropathophysiology of schizophrenia and other neuropsychiatric disorders. Also, the role of altered myelin in the onset and development of schizophrenia and changes in myelin due to ... -
Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity
(2019)Astrocytes are the most numerous cell type in the brain and perform several essential functions in supporting neuronal metabolism and actively participating in neural circuit and behavioral function. They also have ... -
Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease
(2013)Prion diseases are fatal neurodegenerative diseases of the CNS that are associated with the accumulation of misfolded cellular prion protein. There are several different strains of prion disease defined by different patterns ... -
Functional expression of serotonin 5-HT7 receptor in human glioblastoma cell lines
(2004)Serotonin 5‐HT7 receptors are present in astrocytes. Understanding their role in this type of cell would greatly benefit from the identification of astroglial cell lines expressing this receptor type. The aim of the present ... -
Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling
(The Company of Biologists Ltd, 2015)Globoid cell leukodystrophy (Krabbe disease) is a rare infantile neurodegenerative disorder. Krabbe disease is caused by deficiency in the lysosomal enzyme galactocerebrosidase (GALC) resulting in accumulation, in the ... -
How dependent is synaptic plasticity on microglial phenotype?
(2015)Microglia are particularly plastic cells which can be shifted from their resting state by numerous factors and adopt distinct phenotypes. The cells are multifunctional, though their main role is probably maintenance of ... -
Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes.
(2018)A defining pathophysiological hallmark of Alzheimer’s disease (AD) is the amyloid plaque; an extracellular deposit of aggregated fibrillar Aβ1-42 peptides. Amyloid plaques are hard, brittle structures scattered throughout ... -
Investigating the Immune System in Parkinson's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)In 1817 James Parkinson first described the symptoms of the Parkinson's disease (PD). It is the second most common neurodegenerative disease worldwide, and cases are rising exponentially. Characteristic hallmarks of PD ... -
A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus
(Elsevier, 2011)Neuroglial activation is a typical hallmark of ageing within the hippocampus, and correlates with age-related cognitive deficits. We have used quantitative immunohistochemistry and morphometric analyses to investigate ... -
Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia
(2018)Sphingosine 1-phosphate receptors (S1PR) are G protein-coupled and compose a family with five subtypes, S1P1R–S1P5R. The drug Gilenya ® (Novartis, Basel, Switzerland) (Fingolimod; FTY720) targets S1PRs and was the first ... -
Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease.
(2018)Degeneration of the locus coeruleus noradrenergic system is thought to play a key role in the pathogenesis of Parkinson’s disease (PD), whereas pharmacological approaches to increase noradrenaline bioavailability may ...