Browsing by Subject "Blood-brain barrier"
Now showing items 1-6 of 6
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Association of PP2A and VE-cadherin in a mono and co-culture with implications on brain microvascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Introduction: Based on the knowledge that VE-cadherin is an integral component of the functioning endothelium in the blood brain barrier. Its transcellular abundance can be altered by post-translational modifications and ... -
The blood-brain barrier in neuropsychiatric disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Schizophrenia is a severe and disabling mental disorder that affects approximately 1% of the population. Such is the heterogeneous nature of the disease that genetic, neurobiological and environmental factors all contribute ... -
Blood-brain barrier response in the context of sports-related TBI
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)Traumatic brain injury (TBI) is one of the largest causes of mortality and disability globally. The severity of TBI is clinically categorised into mild, moderate and severe injuries. Moderate and severe TBI often present ... -
Identifying Blood-Brain Barrier Pathologies and Novel Therapeutic Targets in Epilepsy and Neuropsychiatric Disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The blood-brain barrier (BBB) is vital for maintaining homeostasis of the neural microenvironment. Tight junctions composed of the transmembrane proteins claudin-5 and occludin contribute to the function of this barrier ... -
Investigating the Role of the 3'UTR of Claudin-5 and Circadian Rhythms at Tight Junctions in the Blood-Brain Barrier
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)The blood-brain barrier (BBB) is comprised of the vasculature surrounding the central nervous system (CNS), and most importantly consists of endothelial cells. These brain endothelial cells have unique properties that ... -
Role of Protein Phosphatase 2A inhibition in modulation of VE-cadherin and Claudin-5 in human brain microvascular endothelial cells and the potential reversal by small molecule activators of PP2A (SMAPs)
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2021)Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase which plays a key role in modulating signalling, metabolism and cell growth, and is implicated in various pathologies. There is conflicting evidence regarding ...