Browsing by Subject "Cornea"
Now showing items 1-12 of 12
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Characterization of extracellular matrix modified poly(¿-caprolactone) electrospun scaffolds with differing fiber orientations for corneal stroma regeneration
(2020)Alternatives to donor cornea transplantation based on tissue engineering are desirable to overcome the current severe donor tissue shortage. Many natural polymers have good biological properties but poor mechanical properties ... -
Decellularization and recellularization of cornea: Progress towards a donor alternative.
(2020)The global shortage of donor corneas for transplantation has led to corneal bioengineering being investigated as a method to generate transplantable tissues. Decellularized corneas are among the most promising materials ... -
Designing Scaffolds for Corneal Regeneration
(2020)Corneal blindness is one of the most common causes of vision loss worldwide, affecting millions of people. To treat these patients, researchers have been examining different approaches to engineer corneal scaffolds suitable ... -
The Effect of Calcium and Glucose Concentration on Corneal Epithelial Cell Lines Differentiation, Proliferation, and Focal Adhesion Expression.
(2019)It is known that culture media composition can affect cell behavior, morphology, and gene expression. However,in the case of corneal epithelial cells, the combined role of calcium and glucose concentration in media has not ... -
The effect of prior long-term recellularization with keratocytes of decellularized porcine corneas implanted in a rabbit anterior lamellar keratoplasty model.
(2021)Decellularized porcine corneal scaffolds are a potential alternative to human cornea for keratoplasty. Although clinical trials have reported promising results, there can be corneal haze or scar tissue. Here, we examined ... -
Engineering a Corneal Stromal Equivalent Using a Novel Multilayered Fabrication Assembly Technique.
(2020)To overcome the serious shortage of donor corneas for transplantation, alternatives based on tissue engineering need to be developed. Decellularized corneas are one potential alternative, but their densely packed collagen ... -
Fabrication and biocompatibility of electroconductive silk fibroin/pedot: Pss composites for corneal epithelial regeneration
(2020)The aim of this study was to develop matrices that can support human corneal epithelial cells and innervation by incorporating a conducting polymer, poly(3,4-ethylenedioxythiophene) poly(styrene sulfonate) (PEDOT:PSS), ... -
Influence of Mechanical Environment on Limbal and Corneal Epithelial Cells
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Corneal blindness is the 4th leading cause of blindness and the most transplanted tissue worldwide. Severe donor shortages and immune rejection has led to research into alternative therapies for corneal transplantation. ... -
Influence of polydimethylsiloxane substrate stiffness on corneal epithelial cells
(2019)Many cell types are known to modulate their behaviour in response to changes in material stiffness; however, little is known about how stiffness affects corneal epithelial cells. This study aims to investigate the response ... -
Potential for combined delivery of riboflavin and all-trans retinoic acid, from silk fibroin for corneal bioengineering.
(2019)Millions of people worldwide suffer from vision impairing conditions resulting from corneal injury or disease. Silk fibroin (SF) is an emerging biopolymer that has been used for several applications including the fabrication ... -
Significance of Crosslinking Approaches in the Development of Next Generation Hydrogels for Corneal Tissue Engineering.
(2021)Medical conditions such as trachoma, keratoconus and Fuchs endothelial dystrophy can damage the cornea, leading to visual deterioration and blindness and necessitating a cornea transplant. Due to the shortage of donor ... -
Silk fibroin based interpenetrating network hydrogel for corneal stromal regeneration
(2022)There is a need to develop tissue engineering based approaches to address the shortage of donor corneas worldwide for transplantation. To do this a novel approach to fabricate three-dimensional hydrogels using free-radical ...