Browsing by Subject "DNA repair"
Now showing items 1-7 of 7
-
The Clinical Applications of Tissue Biomarkers in Prostate Cancer
(2020)The clinical course of localized prostate cancer varies widely, from indolent disease unlikely to need treatment to aggressive disease requiring intensive, multimodal therapy. Traditionally, treatment decisions have been ... -
Development of modified nucleosides for targeting the DNA repair enzyme SNM1A
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Certain cancers exhibit upregulation of DNA interstrand crosslink repair pathways, which contributes to resistance to crosslinking chemotherapy drugs and poor prognoses. Inhibition of enzymes implicated in interstrand ... -
Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents
(National Academy of Sciences, 2011)We investigate yeast sex chromosome evolution by comparing genome sequences from 16 species in the family Saccharomycetaceae, including data from genera Tetrapisispora, Kazachstania, Naumovozyma, and Torulaspora. We show ... -
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
(2019)Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a ... -
Investigations into Metal-Binding Groups to Probe the DNA Repair Nuclease SNM1A
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)SNM1A is a nuclease that is implicated in DNA interstrand crosslink repair and as such is of importance to regular cellular function. However, little is known about its roles, regulation, interaction partners or posttranslational ... -
Nucleoside and Oligonucleotide Modification for Targeting the DNA Damage Repair Enzyme SNM1A
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)The exonuclease SNM1A is a key enzyme involved in the repair of interstrand crosslinks, a highly cytotoxic form of DNA damage. As cells depleted in this enzyme display increased sensitivity to chemotherapeutic agents such ... -
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors
(2019)We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPFERCC1, with a view to ...