Browsing by Subject "Fibrosis"
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Candidate role for TLR3 L412F in disease progression in Idiopathic Pulmonary Fibrosis (IPF) during bacterial and viral infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)In this thesis, we investigated the mechanisms by which TLR3 Leu412Phe (L412F) promotes disease progression in idiopathic pulmonary fibrosis (IPF) patients. IPF is a fatal interstitial lung disease of unknown aetiology and ... -
Immune Dysfunction and Inflammageing in NAFLD
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)With a global prevalence of 25-40%, non-alcoholic fatty liver disease (NAFLD) is fast becoming the commonest cause of liver disease in the developed world [1]. Defined as increased hepatic lipid accumulation, approximately ...