Browsing by Subject "Genomics"
Now showing items 1-9 of 9
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Ancestral Legacies of an Insular Archipelago: A genomic exploration of prehistoric Japan and mainland Asia
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)The objective of this thesis is to use ancient genomic data and a variety of bioinformatic approaches to explore human evolutionary history in the Japanese archipelago and mainland Asia. This thesis presents a dense genomic ... -
Ancient Goat Genomics: Structure, Selection, and Admixture
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)The wild bezoar Capra aegagrus was brought under human control c. 8,000 BC, leading to the domestic goat Capra hircus. This livestock species remains in use 10,000 years later, and is of particular importance to communities ... -
The Contribution of Additional Genetic Variation to CNV Carrier Cognitive and Neurodevelopmental Outcomes
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Many copy number variants (CNV) are strongly associated with neurodevelopmental disorders (NDDs) such as autism, intellectual disability/developmental delay (ID/DD) and schizophrenia. CNVs are large genomic deletions or ... -
Distribution of SCCmec-associated phenol-soluble modulin in staphylococci
(2012)The recently described phenol-soluble modulin PSM-mec was detected in S. aureus, S. epidermidis, S. fleuretti, S. hominis, S. pseudintermedius, S. saprophyticus, S. simulans and S. vitulinus from different hosts (humans, ... -
Inflammation drives alternative first exon usage to regulate immune genes including a novel iron regulated isoform of Aim2
(2021)Determining the layers of gene regulation within the innate immune response is critical to our understanding of the cellular responses to infection and dysregulation in disease. We identified a conserved mechanism of gene ... -
On the Use of Machine Learning in Genomic Prediction
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)This thesis explores the use of machine learning in the context of genomic prediction and the issue of confounding in such approaches. Traditionally, genomic prediction methods have made use of linear models with much ... -
Persistency and genomic tools in forage grasses
Perennial ryegrass (PRG; Lolium perenne) is the most widely cultivated forage grass species in Ireland. Despite its widespread use, there have been meagre gains in the improvement of agronomically important traits, including ... -
Systemic gene dysregulation in classical Galactosaemia: Is there a central mechanism?
(2014)Classical Galactosaemia is a rare disorder of carbohydrate metabolism caused by a deficiency of galactose-1-phosphate uridyltransferase (GALT). The disease is life-threatening in the neonate, and the only treatment option ... -
The york gospels: A 1000-year biological palimpsest
(2017)Medieval manuscripts, carefully curated and conserved, represent not only an irreplaceable documentary record but also a remarkable reservoir of biological information. Palaeographic and codicological investigation can ...