Browsing by Subject "Glucose"
Now showing items 1-9 of 9
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Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3
(PubMed Central, 2005)GSK3 (glycogen synthase kinase-3) regulation is proposed to play a key role in the hormonal control of many cellular processes. Inhibition of GSK3 in animal models of diabetes leads to normalization of blood glucose levels, ... -
Consolidating and re-evaluating the human disc nutrient microenvironment
(2022)Background: Despite exciting advances in regenerative medicine, cell-based strategies for treating degenerative disc disease remain in their infancy. To maximize the potential for successful clinical translation, a more ... -
The Effect of Calcium and Glucose Concentration on Corneal Epithelial Cell Lines Differentiation, Proliferation, and Focal Adhesion Expression.
(2019)It is known that culture media composition can affect cell behavior, morphology, and gene expression. However,in the case of corneal epithelial cells, the combined role of calcium and glucose concentration in media has not ... -
Investigating the physiological relevance of ex vivo disc organ culture nutrient microenvironments using in silico modeling and experimental validation
(2021)Background: Ex vivo disc organ culture systems have become a valuable tool for the development and pre‐clinical testing of potential intervertebral disc (IVD) regeneration strategies. Bovine caudal discs have been widely ... -
Isosteviol has beneficial effects on palmitate-induced cell dysfunction and gene expression.
(2012)BACKGROUND: Long-term exposure to high levels of fatty acids impairs insulin secretion and exaggerates glucagon secretion. The aim of this study was to explore if the antihyperglycemic agent, Isosteviol (ISV), is able ... -
The metabolic determinants of the response to ketone bodies in SH-SY5Y neuroblastoma cells
(Trinity College Dublin. School of Medicine. Discipline of Anatomy, 2020)Neuroblastoma (NB) is a childhood malignancy of the sympathetic nervous system. Its mutual neoplastic and neurodevelopmental underpinnings are characterised by an excessive glucose demand as a hallmark of a high proliferative ... -
Mitochondrial localization of SESN2
(2020)SESN2 is a member of the evolutionarily conserved sestrin protein family found in most of the Metazoa species. The SESN2 gene is transcriptionally activated by many stress factors, including metabolic derangements, reactive ... -
PDK1 regulation of mTOR and Hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
(2012)mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8+ cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the ... -
Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death
(2016)Sestrin2 is a member of a family of stress responsive proteins, which controls cell viability via antioxidant activity and regulation of the mammalian target of rapamycin protein kinase (mTOR). Sestrin2 is induced by ...