Browsing by Subject "IL-17"
Now showing items 1-4 of 4
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Adaptive and Innate TH1 and TH17 Responses in Elderly Hospitalised Patients with Infection and Sepsis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Introduction: Sepsis carries a significant burden to health care. Almost a third of ICU patients have sepsis on admission or develop it during their admission. Sepsis carries a high mortality and affects all age groups ... -
Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
(2010)Experimental autoimmune encephalomyelitis (EAE) is a mouse model for multiple sclerosis, where disease is mediated by autoantigen-specific T cells. Although there is evidence linking CD4+ T cells that secrete IL-17, termed ... -
Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells
(2020)Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this ... -
Metabolic and redox regulation of IL-17-producing γδ T cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Interleukin-17 (IL-17) is a proinflammatory cytokine that contributes to a wide range of immune responses, including host defence, tissue repair, autoimmune inflammation, and tumour progression. γδ17 T cells (CD3+TCRδ+CD27-) ...