Browsing by Subject "IL-6"
Now showing items 1-4 of 4
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Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age
(2021)Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C is frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative disorders ... -
The effects of clozapine and haloperidol on astrocyte function and morphology
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)Schizophrenia is a chronic debilitating psychiatric disorder affecting approximately 1% of the population worldwide. The disorder is characterised by positive symptoms, negative symptoms, and clinical deficits in cognition. ... -
A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1beta, TNF-alpha and IL-6 Challenges in C57BL/6 Mice.
(2013)It is increasingly clear that systemic inflammation has both adaptive and deleterious effects on the brain. However, detailed comparisons of brain effects of systemic challenges with different pro-inflammatory cytokines ...