Browsing by Subject "Immunomodulation"
Now showing items 1-6 of 6
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Altered endotoxin responsiveness in healthy children with Down syndrome.
(2018)Background: Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined ... -
Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial.
(2013)Background There is increasing evidence linking vitamin D deficiency to both susceptibility to, and severity of, multiple sclerosis (MS). Patients with the clinically isolated syndrome represent the initial presentation ... -
The immunomodulatory properties of L-rhamnose
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)L-Rhamnose is a non-mammalian monosaccharide ubiquitously found on the surface of both commensal and pathogenic bacteria. Previous publications had identified that L-rhamnose-rich Mycobacterium tuberculosis glycolipids, ... -
Inhibiting Histone Deacetylases in Human Macrophages Promotes Glycolysis, IL-1β, and T Helper Cell Responses to Mycobacterium tuberculosis
(2020)Tuberculosis (TB) is the leading infectious killer in the world. Mycobacterium tuberculosis (Mtb), the bacteria that causes the disease, is phagocytosed by alveolar macrophages (AM) and infiltrating monocyte-derived ... -
Modulation of immune responses by Fasciola hepatica-derived products
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Helminths are successful pathogens that infect 25% of the world s population. They cause chronic infections that are associated with type-2 and regulatory immune responses that suppress host anti-parasite immune responses. ... -
Modulation of innate and adaptive immunity by Fasciola hepatica
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Helminth parasites have developed highly effective mechanisms of immune subversion that helps prolong their survival in the host, resulting in the development of chronic infections. A bystander effect ...