Browsing by Subject "Inflammatory diseases"
Now showing items 1-2 of 2
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Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory
(2013)Background Cells of the innate immune system including monocytes and macrophages are the first line of defence against infections and are critical regulators of the inflammatory response. These cells express toll-like ... -
ITap, a novel irhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
(eLife Sciences Publications, 2018)The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves ...