Browsing by Subject "Innate Immunity"
Now showing items 1-6 of 6
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The Age-Old Question of ANCA-Associated Vasculitis
(Trinity College Dublin. School of Medicine. Medical Gerontology, 2023)Anti-Neutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis (AAV) is a group of systemic autoimmune disorders characterised by severe inflammation of the small blood vessels. Unusually for an autoimmune disease, ... -
Functional Relevance of Interleukin 8 Haplotype for the Innate Immune System in Holstein-Friesian Cattle
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Calves rely heavily on their innate immune response in the post-birth period before their adaptive immune system develops. Interleukin 8 (IL-8) is a major chemoattractant predominantly associated with neutrophils response ... -
Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network
(2020)The past century has witnessed major advances in the control of many infectious diseases, yet outbreaks and epidemics caused by (re-) emerging RNA viruses continue to pose a global threat to human health. As illustrated ... -
Investigation of the Molluscum Contagiosum Virus Protein MC089 as a Novel Inhibitor of Interferon Regulatory Factor 3 Activation
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2024)Molluscum contagiosum virus (MCV) is a human-specific poxvirus that causes highly common, mild, papular skin lesions. The lesions are notable for exerting minimal to no inflammation but can persist for a long duration ... -
Prevention and treatment of COVID-19 disease by controlled modulation of innate immunity
(2020)The recent outbreak of coronavirus disease 2019 (COVID‐19), triggered by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses an enormous threat to global public health and economies. Human coronaviruses ... -
PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells
(2020)Animal cells use pattern-recognition receptors (PRRs) to detect specific pathogens. Pathogen detection mounts an appropriate immune response, including interferon and cytokine induction. The intracellular PRR-signaling ...