Browsing by Subject "JAK/STAT"
Now showing items 1-4 of 4
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Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway.
(Springer, 2017)Interferon-alpha (IFN-a) is a potent anti-viral cytokine, critical to the host immune response against viruses. IFN-a is first produced upon viral detection by pathogen recognition receptors. Following its expression, IFN-a ... -
Control of HIV infection by IFN-α: implications for latency and a cure.
(Springer, 2018)Viral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence ... -
Hepatitis C Virus targets the Interferon-? JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.
(2013)JAK/STAT signalling is essential for anti-viral immunity, making IFN-α an obvious anti-viral therapeutic. However, many HCV+ patients fail treatment, indicating that the virus blocks successful IFN-α signalling. We found ... -
Investigating the Impact of the Non-Structural Proteins of Respiratory Syncytial Virus on the Type I Interferon Response
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Respiratory syncytial virus is the leading cause of bronchiolitis in infants, causing 33.2 million hospital admissions and over 118,000 deaths each year. The primary site of RSV infection are the epithelial cells of the ...