Browsing by Subject "Mouse model"
Now showing items 1-5 of 5
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Distinct hepatic myeloid and lymphoid cell repertoires are associated with susceptibility and resistance to Ascaris infection
(2021)The soil-transmitted helminth Ascaris lumbricoides infects ~800 million people worldwide. Some people are heavily infected, harbouring many worms, whereas others are only lightly infected. The mechanisms behind this ... -
The Generation and Characterisation of Novel Mouse Models of Haemophilia A
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Haemophilia A (HA) is a hereditary, X-linked recessive disease caused by mutations in the F8 gene, with the absence or deficiency in the coagulation factor, Factor VIII (FVIII), resulting in a bleeding diathesis. The ... -
Hepatic ascariasis in a mouse model of relative susceptibility
(Trinity College Dublin. School of Natural Sciences. Discipline of Zoology, 2020)The parasitic nematode Ascaris lumbricoides infects 800 million people worldwide. The age group most affected by this parasite are children between the ages of 5 and 15 years. The symptoms of ascariasis can be broadly ... -
Non-photoreceptor Expression of Tulp1 May Contribute to Extensive Retinal Degeneration in Tulp1-/- Mice
(2020)Mutations in tubby like protein 1 gene (TULP1) are causative of early-onset recessive inherited retinal degenerations (IRDs); similarly, the Tulp1-/- mouse is also characterized by a rapid IRD. Tulp1 mRNA and protein ... -
p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.
(2019)SESTRINs (SESN1-3) are proteins encoded by an evolutionarily conserved gene family that plays an important role in the regulation of cell viability and metabolism in response to stress. Many of the effects of SESTRINs are ...