Browsing by Subject "NLRP3 inflammasome"
Now showing items 1-4 of 4
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Blood-retina barrier regulation and sterile inflammation in retinal homeostasis and disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is caused by a progressive loss of photoreceptors in the macula, thought to occur secondary to the damage ... -
Diverse Activators of the NLRP3 Inflammasome Promote IL-1ß Secretion by Triggering Necrosis
(2015)The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing “signal I” and diverse agents such as ATP, Nigericin, ... -
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
(2019)The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and ... -
Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes
(2020)Carbon‐based nanomaterials (C‐BNM) have recently attracted an increased attention as the materials with potential applications in industry and medicine. Bioresistance and proinflammatory potential of C‐BNM is the main ...