Browsing by Subject "Neurodevelopment"
Now showing items 1-5 of 5
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An investigation of the role of antenatal depression, maternal cortisol and postnatal interactive behaviour on infant neurodevelopment in the first year of life.
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Abstract Aims: Major Depressive Disorder (MDD) is the most prevalent psychiatric disorder during the perinatal period and can lasting adverse effects on maternal wellbeing and infant development. This aim of this thesis ... -
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
(2020)We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n = 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to integrate de novo and case-control rare variation, ... -
The metabolic determinants of the response to ketone bodies in SH-SY5Y neuroblastoma cells
(Trinity College Dublin. School of Medicine. Discipline of Anatomy, 2020)Neuroblastoma (NB) is a childhood malignancy of the sympathetic nervous system. Its mutual neoplastic and neurodevelopmental underpinnings are characterised by an excessive glucose demand as a hallmark of a high proliferative ... -
Radial glial cells: Key organisers in CNS development.
(2014)Radial glia are elongated bipolar cells present in the CNS during development. Our understanding of the unique roles these cells play has significantly expanded in the last decade. Historically, radial glial cells were ... -
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
(2021)Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms by which H3-K27M causes tumor initiation ...