Browsing by Subject "Oesophageal Cancer"
Now showing items 1-7 of 7
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Characterizing caspase-1 involvement during esophageal disease progression.
(2020)Barrett’s esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation ... -
Enhancing treatment response to neo-adjuvant radiation therapy in oesophageal cancer using novel dual action drugs targeting tumour energy metabolism and angiogenesis
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2019)Oesophageal cancer is an aggressive malignancy associated with a poor 5-year survival of <20%, accounting for over 400,000 deaths each year. The current standard of care for oesophageal adenocarcinoma (OAC) ... -
Exploring the influence of obesity, fatty acids, and current treatment modalities on the immune-metabolic profiles of adipose tissue in oesophageal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current standard of care treatments including chemotherapy and chemoradiotherapy. OAC has one of the strongest associations with ... -
Harnessing natural killer cell-mediated immune responses in obesity-associated cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Oesophagogastric adenocarcinomas (OAC) encompass a group of inflammation-driven and obesity-associated cancers. Poor 5-year survival rates of less than 20% and treatment response rates of less than 30% place these as poor ... -
Multidisciplinary Rehabilitation in Oesophago-gastric Cancer Surviorship
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2018)As survival rates for oesophageal and gastric cancer slowly improve, there has been an emergence of a unique cohort of cancer survivors who present with multifaceted nutritional and physical needs which are amenable to ...