Browsing by Subject "Oesophageal cancer"
Now showing items 1-12 of 12
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Cooperation between chemotherapy and immunotherapy in gastroesophageal cancers
(2020)Gastroesophageal cancers (GOCs) represent some of the most common cancers globally and are linked with poor survival rates. The current standard of care includes multimodal chemotherapy, radiotherapy and surgery. However, ... -
Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett?s oesophagus?.
(2014)Contemporary clinical management of Barrett's oesophagus has highlighted the lack of accurate predictive markers of disease progression to oesophageal cancer. This study aims to examine alterations in mitochondrial energy ... -
Examining the Radiation-induced Bystander Effect (RIBE) and its Effect on Metabolism and Inflammation in Gastrointestinal Cancers
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Radiation therapy is a mainstay of treatment for cancer. However, resistance to therapy remains a major clinical problem in rectal and oesophageal cancer, with at best only 27-30% of patients achieving a complete pathological ... -
Exercise-Based Dysphagia Rehabilitation for Adults with Oesophageal Cancer: a Systematic Review
(2022)Background: Dysphagia is prevalent in oesophageal cancer with significant clinical and psychosocial complications. The purpose of this study was i) to examine the impact of exercise-based dysphagia rehabilitation on clinical ... -
Expression of neuroepithelial transforming gene 1 is enhanced in oesophageal cancer and mediates an invasive tumour cell phenotype.
(2013)Introduction Neuroepithelial Transforming Gene 1 (NET1) is a well characterised oncoprotein and a proven marker of an aggressive phenotype in a number of cancers, including gastric adenocarcinoma. We aimed to investigate ... -
Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma.
(2018)Oesophageal cancer is an aggressive disease with a poor 5 year survival rate of <20% of diagnosed patients. Unfortunately, only 20-30% Oesophageal Adenocarinoma (OAC) patients show a beneficial response to neoadjuvant ... -
The role and treatment potential of natural killer T (NKT) cells in patients with upper gastrointestinal cancers
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)Oesophageal adenocarcinoma (OAC), squamous cell carcinoma (SSC) and gastric cancers (GAC), collectively cause over 1.3 million deaths worldwide reported in 2018. Current therapeutic regimens focus on chemo-radiotherapy ... -
The role of vitamin D and UVB on the risk and survival of oesophageal and gastric cancer
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2018)The Role of Vitamin D and UVB on the Risk and Survival of Oesophageal and Gastric Cancer By Fiona O?Sullivan Background: Vitamin D is a fat-soluble vitamin which has many sources. Currently, there are numerous ways in ... -
Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism
(2017)Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids ... -
Understanding cancer of the oesophagus
(Irish Cancer SocietyIE, 2015) -
Understanding cancer of the oesophagus
(Irish Cancer SocietyIE, 2010) -
Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.
(2019)Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Response to neoadjuvant chemoradiotherapy (NA CRT) is a clinical challenge. We examined if visceral adipose tissue and obesity ...