Browsing by Subject "Osteoarthritis"
Now showing items 1-5 of 5
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Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Early trauma, resulting in focal areas of cartilage damage with injury to the underlying subchondral bone (osteochondral damage) often progresses to arthritis. These so called osteochondral defects (OCDs) can arise from ... -
Disease associated particulates and joint inflammation; mechanistic insights and therapeutic targets
(2018)It is now well established that intra-articular deposition of endogenous particulates, such as osteoarthritis-associated basic calcium phosphate crystals, gout-associated monosodium urate crystals, and calcium deposition ... -
Intra-articular Basic Calcium Phosphate and Monosodium Urate Crystals Inhibit anti-osteoclastogenic Cytokine Signalling
(2016)Objective: Basic calcium phosphate (BCP) and monosodium urate (MSU) crystals are particulates with potent pro-inflammatory effects, associated with osteoarthritis (OA) and gout, respectively. Bone erosion, due to increased ... -
Prescribing patterns of glucosamine in an older population: a national cohort study
(2013)Background Glucosamine is commonly prescribed as a disease modulating agent in osteoarthritis. However, the evidence to date suggests that it has a limited impact on the clinical symptoms of the disease including joint ... -
Surface neuromuscular electrical stimulation for quadriceps strengthening pre and post total knee replacement.
(2010)Background: Total knee replacement has been demonstrated to be one of the most successful procedures in the treatment of osteoarthritis. However quadriceps weakness and reductions in function are commonly reported following ...