Browsing by Subject "Oxygen"
Now showing items 1-5 of 5
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Consolidating and re-evaluating the human disc nutrient microenvironment
(2022)Background: Despite exciting advances in regenerative medicine, cell-based strategies for treating degenerative disc disease remain in their infancy. To maximize the potential for successful clinical translation, a more ... -
A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses.
(2020)Stem cells and the niche in which they reside feature a complex microenvironment with tightly regulated homeostasis, cell-cell interactions and dynamic regulation of metabolism. A significant number of organoid models has ... -
Delayed release singlet oxygen sensitizers based on pyridone-appended porphyrins
(2017)A new type of porphyrin photosensitizer capable of generating singlet oxygen upon irradiation, storing it through binding to pyridone subunits, followed by slow release at 20‐40 °C is reported. The timescale of singlet ... -
FNR is a regulator of Salmonella pathogenicity Island 2 in Salmonella Typhimurium
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)During infection, S. Typhimurium employs Salmonella pathogenicity island (SPI)-encoded type three secretion systems (T3SS) 1 and 2 to invade and survive in host cells. However, expression of SPI-2 is seen at the epithelial ... -
Investigating the physiological relevance of ex vivo disc organ culture nutrient microenvironments using in silico modeling and experimental validation
(2021)Background: Ex vivo disc organ culture systems have become a valuable tool for the development and pre‐clinical testing of potential intervertebral disc (IVD) regeneration strategies. Bovine caudal discs have been widely ...