Browsing by Subject "Photodynamic therapy"
Now showing items 1-11 of 11
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Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity
(2019)Photodynamic therapy is a promising approach for cancer treatment that relies on the administration of a photosensitizer followed by tumor illumination. The generated oxidative stress may activate multiple mechanism of ... -
Covalently cross-linked tetrafunctionalized m-THPC chitosan hydrogels as drug delivery platforms
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Photodynamic therapy (PDT) is an anti-cancer treatment method which uses the combined effect of a photosensitizing drug, light, and oxygen to cause selective damage to target tissue. The second generation photosensitizer ... -
Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis( m-Hydroxyphenyl)porphyrin
(2021)The development of new antimicrobial strategies that act more efficiently than traditional antibiotics is becoming a necessity to combat multidrug-resistant pathogens. Here we report the efficacy of laser-light-irradiated ... -
The good, the bad, and the ugly ? controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy.
(2018)Singlet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable, suffers from poor selectivity and has fast decomposition rates in biological media. Across the scientific community, there is a ... -
In search of strong light-harvesting and long-lived Ru (II) and Ir(III) triplet photosensitisers
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)The Ph.D. thesis begins with a general introduction of triplet photosensitisers and their role in Triplet-Triplet Annihilation Upconversion (TTA-UC). It gives a short literature review of the photophysical properties of ... -
In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy
(2019)The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13–BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad ... -
A lead BODIPY-phenylanthracene dyad for application in photodynamic therapy
(2019)Over the past four years we have developed BODIPY dyads capable of triplet state generation from a charge transfer states generated by photoinduced electron transfer. In the current work we identify a lead compound for ... -
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment
(2020)Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination ... -
Pyrrole-based Photosensitisers for Photomedicine. Synthesis, Photophysical and Photobiological Evaluation of Chlorins and Dipyrrin Complexes
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Photodynamic therapy (PDT) is a light activated therapy which involves a drug-photosensitiser (PS), light, and molecular oxygen. First, the PS is administered via a systemic or topical route and then it accumulates in the ... -
Synthesis and Characterization of Temperature-Sensitive and Chemically Cross-Linked Poly( N-isopropylacrylamide)/Photosensitizer Hydrogels for Applications in Photodynamic Therapy
(2018)A novel poly(N-isopropylacrylamide) (PNIPAM) hydrogel containing different photosensitizers (protoporphyrin IX (PpIX), pheophorbide a (Pba), and protoporphyrin IX dimethyl ester (PpIX-DME)) has been synthesized with a ... -
Synthesis of amphiphilic meso-tetrasubstituted porphyrin-L-amino acid and -heterocyclic conjugates based on m-THPP.
(2018)Two series of amphiphilic meso-tetrasubstituted porphyrin conjugates based on 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin (m-THPP) covalently linked to L-amino acids and heterocycles were synthesized efficiently in the ...