Browsing by Subject "Regulatory T cells"
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Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis
(2019)In this study we examined the metabolic requirements of human T helper cells and the effect of manipulating metabolic pathways in Th17 and Treg cells. The Th17:Treg cell axis is dysregulated in a number of autoimmune or ... -
Fingolimod Attenuates Splenocyte-Induced Demyelination in Cerebellar Slice Cultures
(2014)The family of sphingosine-1-phosphate receptors (S1PRs) is G-protein-coupled, comprised of subtypes S1PR1-S1PR5 and activated by the endogenous ligand S1P. The phosphorylated version of Fingolimod (pFTY720), an oral therapy ... -
The immunoregulatory role of CD4 +FoxP3 +CD25 - regulatory T cells in lungs of mice infected with Bordetella pertussis
(2012)The identification of regulatory T (Treg) cells was originally based on CD25 expression; however, CD25 is also expressed by activated effector T cells. FoxP3 is a more definitive marker of Treg cells, and CD4 +FoxP3 +CD25 ...