Browsing by Subject "Scaffold"
Now showing items 1-10 of 10
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Biomaterial-based endochondral bone regeneration: A shift from traditional tissue engineering paradigms to developmentally inspired strategies
(2019)There is an urgent, clinical need for an alternative to the use of autologous grafts for the ever increasing number of bone grafting procedures performed annually. Herein, we describe a developmentally inspired approach ... -
Cubane and Triptycene as Scaffolds in the Synthesis of Porphyrin Arrays
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)The primary aim of this research was to synthesise multichromophoric arrays that are linked through rigid isolating units with the capacity to arrange the chromophores in a linear and fixed orientation. The electronically ... -
The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia
(2010)Acute myeloid leukaemia (AML) is a cancer of haematopoietic cells that develops in three-dimensional (3-D) bone marrow niches in vivo. The study of AML has been hampered by lack of appropriate ex vivo models that mimic ... -
The development of biomimetic scaffolds for osteochondral tissue engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Articular cartilage (AC) is a soft tissue lining the ends of the bones in our joints. Even minor lesions in AC cause pain, impaired mobility and can develop to osteoarthritis (OA), a disease affecting millions of adults ... -
Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering
(2019)Extracellular matrix (ECM)-derived implants hold great promise for tissue repair, but new strategies are required to produce efficiently decellularized scaffolds with the necessary porosity and mechanical properties to ... -
Growth plate extracellular matrix-derived scaffolds for large bone defect healing
(2017)Limitations associated with demineralised bone matrix and other grafting materials have motivated the development of alternative strategies to enhance the repair of large bone defects. The growth plate (GP) of developing ... -
Layered double hydroxide as a potent non-viral vector for nucleic acid delivery using gene-activated scaffolds for tissue regeneration applications
(2020)Nonviral vectors offer a safe alternative to viral vectors for gene therapy applications, albeit typically exhibiting lower transfection efficiencies. As a result, there remains a significant need for the development of a ... -
Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus - Effect of TGF-β3 supplementation and oxygen culture conditions
(2014)Disc herniation as a result of degenerative or traumatic injury is believed to be the primary instigator of low back pain. At present there is a lack of viable treatment options to repair damaged annulus fibrosus tissue ... -
Significance of Crosslinking Approaches in the Development of Next Generation Hydrogels for Corneal Tissue Engineering.
(2021)Medical conditions such as trachoma, keratoconus and Fuchs endothelial dystrophy can damage the cornea, leading to visual deterioration and blindness and necessitating a cornea transplant. Due to the shortage of donor ... -
Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues
(2019)Biological scaffolds generated from tissue-derived extracellular matrix (ECM) are commonly used clinically for soft tissue regeneration. Such biomaterials can enhance tissue-specific differentiation of adult stem cells, ...