Browsing by Subject "Signal transduction"
Now showing items 1-3 of 3
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CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression
(Wiley, 2009)The chemokine eotaxin/CCL11 is an important mediator of leukocyte migration, but its effect on inflammatory cytokine signaling has not been explored. In this study, we find that CCL11induces suppressor of cytokine signaling ... -
The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease.
(2014)The innate immune response depends on the ability of immune cells to detect pathogens through germline-encoded pattern recognition receptors (PRRs). Recently discovered PRRs include some members of the Pyrin and HIN domain ... -
Phosphorylation of Rab5a protein by protein kinase Cϵ Is crucial for T-cell migration
(2014)Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we ...