Browsing by Subject "Spine"
Now showing items 1-3 of 3
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Development and Functional Assessment of a Decellularised Injectable Biomaterial Combined with Nasal Chondrocytes for Intervertebral Disc Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Lower Back Pain (LBP) is known to be a major health issue worldwide with a significant socioeconomic impact and it is widely accepted that LBP is associated with degeneration of the intervertebral disc (IVD). IVD degeneration ... -
Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration
(2020)Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden. The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated ... -
Synergistic Effects of Acidic pH and Pro-Inflammatory Cytokines IL-1β and TNF-α for Cell-Based Intervertebral Disc Regeneration
(2020)The intervertebral disc (IVD) relies mainly on diffusion through the cartilaginous endplates (CEP) to regulate the nutrient and metabolites exchange, thus creating a challenging microenvironment. Degeneration of the IVD ...