Browsing by Subject "TLR"
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An Analysis of Glutathionylation in the Modulation of the Critical Innate Immune Regulators Mal and NEK7
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Macrophages are critical innate immune cells that sense pathogen associated molecular patterns (PAMPs) and host-derived damage associated molecular patterns (DAMPs) through specialized Toll-like receptors (TLRs) to maintain ... -
TLR, NLR agonists, and other immune modulators as infectious disease vaccine adjuvants
(2010)Vaccines based on attenuated or killed viruses and bacteria are highly effective in preventing infection with a range of pathogens, but can have safety issues. Therefore, there is a move towards subunit vaccines based ... -
TLR-dependent T cell activation in autoimmunity.
(2011)Autoimmune disease can develop as a result of a breakdown in immunological tolerance, leading to the activation of self-reactive T cells. There is an established link between infection and human autoimmune diseases. ...