Browsing by Subject "TLR4"
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A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
(PLoS, 2007)The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer membrane of Gram negative ... -
IL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice
(2011)Single-Ig-interleukin-1 related receptor (SIGIRR) is a member of the interleukin (IL)-1/Toll-like receptor (TLR) family. It negatively regulates inflammation, rendering SIGIRR-/- mice more susceptible to inflammatory ... -
Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule
(2010)TLRs are critical pattern recognition receptors, which recognize bacterial and viral pathogen associated molecular patterns leading to innate and adaptive immune responses. TLRs signal via homotypic interactions between ...