Browsing by Subject "TNF-α"
Now showing items 1-4 of 4
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Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age
(2021)Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C is frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative disorders ... -
Evaluating the role of angiogenesis in disease behaviour and therapy response in ulcerative colitis
Introduction Ulcerative colitis (UC) is a chronic inflammatory condition with a significant impact on quality of life. In this thesis two small molecule anti-angiogenic and anti-inflammatory agents were used to treat tissue ... -
The role of lymphocytes in neonatal encephalopathy.
(2021)Neonatal encephalopathy is a syndrome characterised by abnormal neurological function often caused by a hypoxic insult during childbirth. Triggers such as hypoxia-ischaemia result in the release of cytokines and chemokines ... -
The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation.
(2020)Background: Only 10-30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and angiogenic mediators in the tumour microenvironment ...