Browsing by Subject "Toll-Like Receptors"
Now showing items 1-4 of 4
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Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.
(2015)The circadian clock allows an organism to anticipate daily changes imposed by the environment. The response to LPS is altered depending on time of day; however, the molecular mechanisms underlying this are unclear. We find ... -
Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense
(2019)The mammalian innate immune system deals with invading pathogens and stress by activating pattern-recognition receptors (PRRs) in the host. Initially proposed to be triggered by the discrimination of defined molecular ... -
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
(2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ...