Browsing by Subject "Trypanosoma brucei"
Now showing items 1-4 of 4
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Characterisation of Membrane Glycoproteins that are Essential for Flagellar Attachment in the Bloodstream Form of Trypanosoma brucei
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)The African trypanosome, Trypanosoma brucei, is a unicellular parasitic protist that causes a severe disease, trypanosomiasis, in humans and livestock in sub-Saharan Africa. The trypanosome has a single flagellum that ... -
A differential role for actin in the life cycle of T. brucei.
(Nature Publishing Group, 2004)Actin is expressed at similar levels but in different locations in bloodstream and procyclic forms of Trypanosoma brucei. In bloodstream forms actin colocalizes with the highly polarized endocytic pathway, whereas in ... -
Exploration of a novel class of HO-1 inducers as potential therapeutics for inflammatory disease
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Autoimmune and inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, and inflammatory bowel disease (IBD) are characterised by excessive and uncontrolled inflammation. Most of these ... -
Metabolic reprogramming during the Trypanosoma brucei life cycle
(2017)Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental ...