Browsing by Subject "Virology"
Now showing items 1-7 of 7
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DIFFERENTIAL FILAMENTATION OF CANDIDA ALBICANS AND C. DUBLINIENSIS IS GOVERNED BY NUTRIENT REGULATION OF UME6 EXPRESSION
(2010)Candida dubliniensis is closely related to Candida albicans; however, it is responsible for fewer infections in humans and is less virulent in animal models of infection. C. dubliniensis forms fewer hyphae in vivo, and ... -
Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network
(2020)The past century has witnessed major advances in the control of many infectious diseases, yet outbreaks and epidemics caused by (re-) emerging RNA viruses continue to pose a global threat to human health. As illustrated ... -
An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo.
(2012)Influenza viruses readily mutate by accumulating point mutations and also by reassortment in which they acquire whole gene segments from another virus in a co-infected host. The NS1 gene is a major virulence factor of ... -
Investigating the Impact of the Non-Structural Proteins of Respiratory Syncytial Virus on the Type I Interferon Response
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Respiratory syncytial virus is the leading cause of bronchiolitis in infants, causing 33.2 million hospital admissions and over 118,000 deaths each year. The primary site of RSV infection are the epithelial cells of the ... -
Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility.
(2013)The H5N1 influenza A viruses have circulated widely in the avian population for 10 years with only sporadic infection of humans observed and no sustained human to human transmission. Vaccination against potential pandemic ... -
A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets.
(2011)he first pandemic of the 21 st century, pandemic H1N1 2009 (pH1N1 2009), emerged from a swine-origin source. Although human infections with swine-origin influenza have been reported previously, none went on to cause a ... -
Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model.
(2012)During the early phase of the 2009 influenza pandemic, attempts were made to contain the spread of the virus. Success of reactive control measures may be compromised if the proportion of transmission that occurs before ...