Browsing by Subject "autoimmunity"

Now showing items 1-4 of 4

    • Association of clinical phenotype and genetic burden in coeliac disease 

      DOMINGUEZ CASTRO, PATRICIA (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)
      Coeliac disease (CD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to a gluten containing diet in genetically predisposed individuals. The clinical presentation of CD is highly ...

    • Immune dysfunction in the skin disease hidradenitis suppurativa 

      MORAN, BARRY (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)
      Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease. Painful lesions and boils present at hair follicles of the inframammary fold, genitals, groin, buttocks and perianal areas. Severe cases ...

    • Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease. 

      LAVELLE, EDWARD; MILLS, KINGSTON; LALOR, STEPHEN (2009)
      IL-17 producing CD4+ T (Th17) cells are pathogenic in many autoimmune diseases. The induction and expansion of Th17 cells is directed by cytokines, including IL-23 and IL-1?, produced by innate immune cells through ...

    • TLR-dependent T cell activation in autoimmunity. 

      MILLS, KINGSTON (2011)
      Autoimmune disease can develop as a result of a breakdown in immunological tolerance, leading to the activation of self-reactive T cells. There is an established link between infection and human autoimmune diseases. ...