Browsing by Subject "cGAS-STING"
Now showing items 1-3 of 3
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C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages
(2023)The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages. ... -
An Emerging Role for Type I Interferons as Critical Regulators of Blood Coagulation
(2023)Type I interferons (IFNs) are central mediators of anti-viral and anti-bacterial host defence. Detection of microbes by innate immune cells via pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and ... -
Particulate adjuvants for use in cancer vaccination
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)It is estimated that 1 in 2 people will develop cancer in their lifetime, highlighting the urgent need for improved preventative and therapeutic strategies. Cancer immunotherapy has emerged as a key pillar of cancer ...