Now showing items 1-3 of 3

    • Development of gene therapies for retinal degenerations 

      Shortall, Ciara (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)
      The studies described in this thesis explore potential gene therapies for retinal degenerative diseases using adeno-associated virus (AAV) vectors for gene delivery. Inherited retinal degenerations (IRDs) are a leading ...
    • Novel therapeutic approaches for open-angle glaucoma 

      Kelly, Ruth (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)
      Glaucoma is the leading cause of blindness worldwide after cataracts and it is estimated that the global prevalence of glaucoma will increase to 111.8 million by 2040 (1, 2). Primary open-angle glaucoma (POAG) is characterized ...
    • Study of Macular Pigments in Glaucoma 

      Siah, We Fong (Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)
      The macula can be involved in the early stage of glaucoma, as evidenced by the presence of paracentral scotoma on visual field tests (Drance 1969) or thinning of the ganglion cell complex (GCC) layer on optical coherence ...