Browsing by Subject "microglia"
Now showing items 1-5 of 5
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Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL
(2012)Altered synaptic morphology, progressive loss of synapses and glial (astrocyte and microglial) cell activation are considered as characteristic hallmarks of ageing. Recent evidence suggests that there is a concomitant ... -
Exercise has persistent effects on learning and memory throught the lifespan: Analysis of the underlying mechanisms
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2018)Ageing is a complex process associated with a decline in organism functions. Ageing affects several cellular and molecular brain mechanisms and is commonly associated with decline in brain function, such as cognition and ... -
Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration
(2022)As the resident immune cells in the retina, microglia play important homeostatic roles in retinal immune regulation and neuroprotection. However, chronic microglia activation is a common hallmark of many degenerative retinal ... -
SIGIRR modulates the inflammatory response in the brain
(Elsevier, 2010)One of the more recently described members of the interleukin-1 (IL-1) receptor family, single-Ig-Interleukin-1 related receptor (SIGIRR), has been identified as a negative regulator of inflammation in several tissues. ... -
A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1beta, TNF-alpha and IL-6 Challenges in C57BL/6 Mice.
(2013)It is increasingly clear that systemic inflammation has both adaptive and deleterious effects on the brain. However, detailed comparisons of brain effects of systemic challenges with different pro-inflammatory cytokines ...