Browsing by Subject "neurodegeneration"
Now showing items 1-5 of 5
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Decreased activation along the dorsal visual pathway after a 3-month treatment with Galantamine in mild Alzheimer's disease
(Wolters Kluwer, 2009)Visual perception has been shown to be altered in Alzheimer?s disease (AD) patients and it is associated with decreased cognitive function. Galantamine is an active cholinergic agent, which has been shown to lead to ... -
Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1 beta and IL-6
(2011)Abstract: Background: Chronic neurodegeneration comprises an inflammatory response but its contribution to the progression of disease remains unclear. We have previously shown that microglial cells are primed by chronic ... -
Exploration of gene therapies targeting oxidative stress and NAD+ pathways for the treatment of optic neuropathy
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The World Health Organisation estimates that there are approximately 300 million people suffering from some form of blindness, from inherited retinal degenerations to complex diseases such as glaucoma. The vast heterogeneity ... -
Resting-state electroencephalographic biomarkers for tracking cognitive network dysfunction in amyotrophiclateral sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) stands as a multifaceted neurological disorder that primarily affects both upper and lower motor neurons. However, research in neuroimaging, neuropsychology and neurobiology has shown ... -
Worsening Cognitive Impairment and Neurodegenerative Pathology Progressively Increase Risk for Delirium.
(2015)Background Delirium is a profound neuropsychiatric disturbance precipitated by acute illness. Although dementia is the major risk factor this has typically been considered a binary quantity (i.e., cognitively impaired ...