The Photosensitizer Temoporfin (mTHPC) - Chemical, Pre-clinical and Clinical Developments in the Last Decade
Citation:
Wiehe A, Senge MO. The Photosensitizer Temoporfin (mTHPC) - Chemical, Pre-clinical and Clinical Developments in the Last Decade. Photochemistry and Photobiology. 2023 Mar;99(2):356-419Download Item:
Abstract:
This review follows the research, development and clinical applications of the photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (mTHPC, temoporfin) in photodynamic (cancer) therapy (PDT) and other medical applications. Temoporfin is the active substance in the medicinal product Foscan® authorized in the EU for the palliative treatment of head and neck cancer. Chemistry, biochemistry and pharmacology, as well as clinical and other applications of temoporfin are addressed, including the extensive work that has been done on formulation development including liposomal formulations. The literature has been covered from 2009 to early 2022, thereby connecting it to the previous extensive review on this photosensitizer published in this journal [Senge, M. O. and J. C. Brandt (2011) Photochem. Photobiol. 87, 1240-1296] which followed its way from initial development to approval and clinical application.
Author's Homepage:
http://people.tcd.ie/sengem
Author: Senge, Mathias
Type of material:
Journal ArticleCollections
Series/Report no:
Photochemistry and Photobiology;Availability:
Full text availableDOI:
http://dx.doi.org/10.1111/php.13730Metadata
Show full item recordLicences: