Browsing Genetics (Scholarly Publications) by Title
Now showing items 109-128 of 357
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A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities
(2018)The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 ... -
Faster Evolving Primate Genes Are More Likely to Duplicate
(2018)An attractive and long-standing hypothesis regarding the evolution of genes after duplication posits that the duplication event creates new evolutionary possibilities by releasing a copy of the gene from constraint. Apparent ... -
Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma
(2021)Previous studies have shown that glaucomatous Schlemm’s canal endothelial cells (gSCECs) are stiffer and associated with reduced porosity and increased extracellular matrix (ECM) material compared to SCECs from healthy ... -
Fly model causes neurological rethink
(2013)A Drosophila model for a neurological disorder called type 2B Charcot- Marie-Tooth disease reveals that it has its origins in a partial loss of function, rather than a gain of function, which points to the need for ... -
Following the genes: a framework for animal modeling of psychiatric disorders.
(2011)The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models ... -
Fourfold faster rate of genome rearrangement in nematodes than in Drosophila
(2002)We compared the genome of the nematode Caenorhabditis elegans to 13% of that of Caenorhabditis briggsae, identifying 252 conserved segments along their chromosomes. We detected 517 chromosomal rearrangements, with the ratio ... -
Functional conservation of an ancestral Pellino protein in helminth species
(2015)The immune system of H. sapiens has innate signaling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms such as ... -
Functional Diversification of the Twin-Arginine Translocation Pathway Mediates the Emergence of Novel Ecological Adaptations
(2011)Microorganisms occupy a myriad of ecological niches that show an astonishing diversity. The molecular mechanisms underlying microbes? ecological diversity remain a fundamental conundrum in evolutionary biology. Evidence ... -
Functional Partitioning of Yeast Co-Expression Networks after Genome Duplication
(Public Library of Science, 2006)Several species of yeast, including the baker?s yeast Saccharomyces cerevisiae, underwent a genome duplication roughly 100 million years ago. We analyze genetic networks whose members were involved in this duplication. ... -
Further notes on the genealogy and social history of the Carlow family of John Tyndall (1820-1893)
(2013)Using local information and early correspondence we trace aspects of the history of the Carlow family of John Tyndall, concentrating particularly on his sister Emma and several hitherto unknown incidents in her life and ... -
A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor
(2012)Transcription factor codes play an essential role in neuronal specification and axonal guidance in both vertebrate and invertebrate organisms. However, how transcription codes regulate axon pathfinding remains poorly ... -
Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity
(2015)Neurodevelopmental disorders arise from single or multiple gene defects. However, the way multiple loci interact to modify phenotypic outcomes remains poorly understood. Here, we studied phenotypes associated with mutations ... -
Gene expression changes during retinal development and rod specification
(2015)Purpose: Retinitis pigmentosa (RP) typically results from individual mutations in any one of >70 genes that cause rod photoreceptor cells to degenerate prematurely, eventually resulting in blindness. Gene therapies ... -
Gene expression profiles during early differentiation of mouse embryonic stem cells
(2009)Background Understanding the mechanisms controlling stem cell differentiation is the key to future advances in tissue and organ regeneration. Embryonic stem (ES) cell differentiation can be triggered by embryoid body ... -
Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection.
(2011)African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more ... -
Genetic evidence of African slavery at the beginning of the Trans-Atlantic slave trade
(2014)An archaeological excavation in Valle da Gafaria (Lagos, Portugal), revealed two contiguous burial places outside the medieval city walls, dating from the 15th-17th centuries AD: one was interpreted as a Leprosarium cemetery ...