Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Title
Now showing items 292-311 of 445
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Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation
(2011)The present study investigated the effect of operating parameters of a laboratory spray dryer on powder characteristics, in order to optimise the production of trehalose and raffinose powders, intended to be used as carriers ... -
Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating
(2018)Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the ... -
Part Two: Evaluation of N-methylbupropion as a Potential Bupropion Prodrug
(2014)N-methylbupropion was selected as a potential prodrug from our in vitro screening of analogues of bupropion described in the preceding paper. This study describes in vivo pharmacokinetics of N-methylbupropion in the ... -
Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery
(2011)The pulmonary route of delivery offers a potential alternative to parenteral administration of peptides and proteins. Protection of protein structure is essential in both processing and storage of the final formulation. ... -
Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate
(2011)Sodium cromoglicate is an antiasthmatic and antiallergenic drug used in inhalation therapy and commonly administered by a dry powder inhaler. In the present study we sought to examine the feasibility of producing nanoporous ... -
The particle has landed - characterizing the fate of inhaled pharmaceuticals
(2010)Although there is a modest body of literature on the absorption of inhaled pharmaceuticals by normal lungs and some limited information from diseased lungs, there is still a surprising lack of mechanistic knowledge about ... -
Pentacyclic triterpenes modulate farnesoid X receptor expression in colonic epithelial cells: implications for colonic secretory function.
(2022)The nuclear bile acid receptor, farnesoid X receptor (FXR), is an important regulator of intestinal and metabolic function. Previous studies suggest that pentacyclic triterpenes (PCTs), a class of plant-derived bioactive ... -
Personal Electronic Records of Medications (PERMs) for medication reconciliation at care transitions: a rapid realist review.
(2021)Background Medication reconciliation (MedRec), a process to reduce medication error at care transitions, is labour- and resource-intensive and time-consuming. Use of Personal Electronic Records of Medications (PERMs) ... -
Pharmaceutical policy - health strategy working paper
(2002)Working paper in response to govenment Health Strategy 'Quality and Fairness A health System for you'. It looks at the priority policy areas for development neglected in the Health Strategy; Community Pharmacy, Hospital ... -
Pharmacists involvement in COVID-19 vaccination across Europe: A situational analysis of current practice and policy
(2021)One year since the emergence of the COVID-19 pandemic, rapid response measures have been implemented internationally to mitigate the spread of the virus. Following rapid and successful pre-clinical and human trials, several ... -
Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride
(2014)BACKGROUND: Silver nanoparticles (AgNPs) and fluoride (F) are pharmacological agents widely used in oral medicine and dental practice due to their anti-microbial/anti-cavity properties. However, risks associated with ... -
Pharmacological effects of a novel isosorbide-based butyrylcholinesterase inhibitor
(2008)Isosorbide-2-benzylcarbamate-5-benzoate, a novel butyrylcholinesterase inhibitor, shows interspecies variation in its inhibitory activity (IC50 of 4.3 nM for human plasma butyrylcholinesterase, but 1.09 ?M for mouse plasma ...