Pharmacy and Pharmaceutical Sciences (Scholarly Publications): Recent submissions
Now showing items 21-40 of 445
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Pentacyclic triterpenes modulate farnesoid X receptor expression in colonic epithelial cells: implications for colonic secretory function.
(2022)The nuclear bile acid receptor, farnesoid X receptor (FXR), is an important regulator of intestinal and metabolic function. Previous studies suggest that pentacyclic triterpenes (PCTs), a class of plant-derived bioactive ... -
Carissa spinarum L.: A Case Study in Ethnobotany and Bioprospecting Research
(Intech Open, 2022)This study explores ethnobiological and bioprospecting research through the lens of Carissa spinarum L., using it as a case study to examine wider trends in such research. Hunn’s Phasing in Ethnobiology is used as a ... -
Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications
(2021)Medicinal plants have been used for a very long time to improve human health; they are gaining increasing popularity globally as drugs, complementary and alternative medicines, food supplements, cosmetics and, more surprisingly, ... -
Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?
(2020)Many behavioral and psychological symptoms of dementia (BPSD) share similarities in executive functioning and communication deficits with those described in several neuropsychiatric disorders, including Alzheimer’s disease ... -
Exploring the Irish National Folklore Ethnography Database (Dúchas) for Open Data Research on Traditional Medicine Use in Post-Famine Ireland: An Early Example of Citizen Science
(2020)A rich archive of oral and ethnological literature is housed in the National Folklore Collection, in University College Dublin, Ireland. The Schools' Manuscript Collection is one body of information that contains a wealth ... -
Medicine Maker: An Outreach Activity for Pharmaceutical Manufacturing and Health Literacy
(2022)Public engagement in medicine has become more important in promoting population health management and literacy. Medicine is a topic of great societal importance, and many public engagement activities have been developed ... -
Pre-Clinical In Vitro Models Used in Cancer Research: Results of a Worldwide Survey
(2021)To develop and subsequently get cancer researchers to use organotypic three-dimensional (3D) models that can recapitulate the complexity of human in vivo tumors in an in vitro setting, it is important to establish what in ... -
A method of separating extracellular vesicles from blood shows potential clinical translation, and reveals extracellular vesicle cargo gremlin-1 as a diagnostic biomarker
(2022)Extracellular vesicles (EVs) have potential as minimally invasive biomarkers. However, the methods most commonly used for EV retrieval rely on ultracentrifugation, are time-consuming, and unrealistic to translate to ... -
Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles
(2021)The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field-consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was ... -
Extracellular vesicle separation from milk and infant milk formula using acid precipitation and ultracentrifugation
(2021)Separation of highly enriched extracellular vesicles (EVs) fractions from milk is desirable for quantification, cargo analysis, functional characterization, and investigation as delivery vehicles for nutrients and/or ... -
Interprofessional Education focused on Medication Safety: A Systematic Review.
(2022)Safe medication use necessitates interprofessional working, with calls to enhance interprofessional education (IPE) focusing on medication safety (MS) in healthcare professional (HCP) curricula. Little is known about the ... -
Submerged Eutectic-Assisted, Solvent-Free Mechanochemical Formation of a Propranolol Salt and Its Other Multicomponent Solids
(2021)Salt preparation via a solid-state reaction offers a solution to challenges posed by current pharmaceutical research, which include combining development of novel forms of active pharmaceutical ingredients with greener, ... -
Characterisation and fundamental insight into the formation of new solid state, multicomponent systems of propranolol.
(2021)The physiochemical properties of acidic or basic active pharmaceutical ingredients (APIs) can be optimised by forming salts with different counterions. The aim of this work was to synthesise a novel salt of propranolol ... -
High-Pressure Dielectric Studies-a Way to Experimentally Determine the Solubility of a Drug in the Polymer Matrix at Low Temperatures
(2021)In this work, we employed broad-band dielectric spectroscopy to determine the solubility limits of nimesulide in the Kollidon VA64 matrix at ambient and elevated pressure conditions. Our studies confirmed that the solubility ... -
Formation of low melting point binary systems comprising ketoprofen and an amide local anaesthetic
(2021)Liquid forms of active pharmaceutical ingredients, ionic liquids (ILs) and deep eutectic mixtures (DEMs), offer several potential benefits in respect to advancing pharmaceutical formulations. The aim of this study was to ... -
Formation of stoichiometric and non-stoichiometric ionic liquid and cocrystal multicomponent phases of lidocaine with azelaic acid by changing counterion ratios
(2021)Tuning of physicochemical properties of ionic liquids and crystalline materials is a challenge that opens up unlimited possibilities for expanding applications and controlling biological activity of pharmaceutical ... -
Personal Electronic Records of Medications (PERMs) for medication reconciliation at care transitions: a rapid realist review.
(2021)Background Medication reconciliation (MedRec), a process to reduce medication error at care transitions, is labour- and resource-intensive and time-consuming. Use of Personal Electronic Records of Medications (PERMs) ... -
Extracellular vesicle separation from milk and infant milk formula using acid precipitation and ultracentrifugation
(2021)Separation of highly enriched extracellular vesicles (EVs) fractions from milk is desirable for quantification, cargo analysis, functional characterization, and investigation as delivery vehicles for nutrients and/or ... -
Evidence for the Need to Evaluate More Than One Source of Extracellular Vesicles, Rather Than Single or Pooled Samples Only, When Comparing Extracellular Vesicles Separation Methods
(2021)To study and exploit extracellular vesicles (EVs) for clinical benefit as biomarkers, therapeutics, or drug delivery vehicles in diseases such as cancer, typically we need to separate them from the biofluid into which they ...