dc.contributor.author | KELLEHER, DERMOT P | |
dc.date.accessioned | 2009-10-07T10:08:15Z | |
dc.date.available | 2009-10-07T10:08:15Z | |
dc.date.issued | 2007 | |
dc.date.submitted | 2007 | en |
dc.identifier.citation | Windle HJ, Kelleher D, Crabtree JE `Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle?? in Paediatrics, 119, (3), 2007, pp e754 - e759 | en |
dc.identifier.other | Y | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/33809 | |
dc.description | PUBLISHED | en |
dc.description.abstract | We hypothesize that infection with the gastric pathogen Helicobacter pylori in children in developing countries is the initiator of a vicious cycle of events that result ultimately in malnutrition and growth impairment. Acute infection with H. pylori is accompanied by hypochlorhydria, which facilitates the acquisition of other enteropathogens because of removal of the gastric acid barrier, which then results in diarrheal disease and iron-deficiency anemia. This is likely to occur most frequently in developing regions where the prevalence of H. pylori infection is disproportionately high and multiple enteric coinfections are common. The consequent synergistic impact of diarrheal disease and micronutrient deficiency on growth and cognitive function in children has significant public health implications for socioeconomic development in these countries. | en |
dc.description.sponsorship | Work in the laboratories of Drs Windle and Kelleher is supported by the Health Research Board, Enterprise Ireland, the European Union (EU), and the Higher Education Authority. Work in the laboratory of Dr Crabtree is supported by Yorkshire Cancer Research and the European Union (EU). We are funded under the Sixth Framework Program of the European Union (EU), Project CONTENT (INCO-CT-2006-032136) | en |
dc.format.extent | e754 | en |
dc.format.extent | e759 | en |
dc.format.extent | 415553 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.publisher | American Academy of Paediatrics | en |
dc.relation.ispartofseries | Paediatrics | en |
dc.relation.ispartofseries | 119 | en |
dc.relation.ispartofseries | 3 | en |
dc.rights | Y | en |
dc.subject | H pylori ? hypochlorhydria ? diarrhea ? enteric infections ? iron-deficiency anemia ? malnutrition | en |
dc.title | Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle? | en |
dc.type | Journal Article | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/kellehdp | |
dc.identifier.rssinternalid | 40248 | |
dc.identifier.rssuri | http://dx.doi.org/10.1542/peds.2006-2196 | |
dc.contributor.sponsor | Health Research Board | |
dc.contributor.sponsor | Enterprise Ireland | |
dc.contributor.sponsor | Higher Education Authority | |
dc.contributor.sponsor | European Union (EU) | |