dc.contributor.author | KELLEHER, DERMOT P | |
dc.date.accessioned | 2009-10-23T18:03:10Z | |
dc.date.available | 2009-10-23T18:03:10Z | |
dc.date.issued | 1994 | |
dc.date.submitted | 1994 | en |
dc.identifier.citation | X. J. Fan, A. Chua, C. N. Shahi, J. McDevitt, P. W. Keeling and D. Kelleher `Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation? in Gut, 35, (10), 1994, pp 1379-1384 | en |
dc.identifier.other | Y | en |
dc.identifier.other | Y | |
dc.identifier.other | 21334 | |
dc.identifier.uri | http://hdl.handle.net/2262/34212 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Helicobacter pylori has been identified as a dominant factor in the pathogenesis of duodenal ulcer. The aim of this study was to examine peripheral blood and gastric lymphocyte proliferation and cytokine production in patients with H pylori colonisation. Sixty five dyspeptic patients attending for endoscopy were studied; 35 of these were H pylori positive and 30 H pylori negative as assessed by culture, histology, and rapid urease test. H pylori antigen was capable of stimulating peripheral blood lymphocyte proliferative responses even in H pylori negative patients. Peripheral blood lymphocyte proliferative responses to H pylori (but not to purified protein derivative or phythaemagglutinin) were significantly lower in H pylori positive than H pylori negative patients. Similarly, antigen specific proliferative responses and interferon gamma production by gastric lamina propria lymphocytes were also depressed in H pylori positive patients compared with H pylori negative patients. CD8 and CD22 positive lamina propria lymphocytes were increased in H pylori positive patients. These data show that antigen specific responses to H pylori are significantly lower in H pylori positive patients and could indicate activation of antigen specific suppression. | en |
dc.format.extent | 1379-1384 | en |
dc.format.extent | 1316398 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.publisher | BMJ | en |
dc.relation.ispartofseries | Gut | en |
dc.relation.ispartofseries | 35 | en |
dc.relation.ispartofseries | 10 | en |
dc.rights | Y | en |
dc.subject | Clinical Medicine | en |
dc.title | Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/kellehdp | |
dc.identifier.rssuri | http://dx.doi.org/10.1136/gut.35.10.1379 | |