dc.contributor.author | Reilly, Richard | en |
dc.contributor.author | Whelan, Robert | en |
dc.date.accessioned | 2010-10-17T16:20:43Z | |
dc.date.available | 2010-10-17T16:20:43Z | |
dc.date.issued | 2010 | en |
dc.date.submitted | 2010 | en |
dc.identifier.citation | Whelan, R, Lonergan, R, Kiiski, H, Nolan, H, Kinsella, K, Hutchinson, M, Tubridy, N, Reilly, RB, Impaired information processing speed and attention allocation in multiple sclerosis patients versus controls: A high-density EEG study, Journal of the Neurological Sciences, 293, 1-2, 2010, 45-50 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/41101 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Background: The no-go P3a is a variant of the P300 event-related potential
(ERP) that indexes speed of information processing and attention allocation.
The aim of this study was to compare ERP findings with results from the
paced auditory serial addition test (PASAT) and quantify latency, amplitude
and topographical differences in P3a ERP components between multiple
sclerosis (MS) patients and controls.
Patients and Methods: Seventy-four subjects (20 relapsing remitting (RRMS)
patients, 20 secondary progressive (SPMS) patients and 34 controls)
completed a three-stimulus oddball paradigm (target, standard, nontarget).
Subjects participated in separate visual and auditory tasks while data were
recorded from 134 EEG channels. Latency differences were tested using an
ANCOVA. Topographical differences were tested using statistical parametric
mapping.
Results: Visual P3a amplitude correlated with PASAT score in all MS patients
over frontal and parietal areas. There were significant differences in latency,
amplitude, and topography between MS patients and controls in the visual
condition. RRMS and SPMS patients differed in visual P3a latency and
amplitude at frontal and parietal scalp regions. In the auditory condition, there
were latency differences between MS patients and controls only over the
parietal region.
Conclusion: The present results demonstrate that information processing
speed and attention allocation are impaired in MS. | en |
dc.description.sponsorship | This study was partly funded by an Enterprise Ireland grant to R.B.
Reilly (eBiomed: eHealthCare based on Biomedical Signal Processing and
ICT for Integrated Diagnosis and Treatment of Disease) and by a Science
Foundation Ireland grant to R.B. Reilly | en |
dc.format.extent | 45-50 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Journal of the Neurological Sciences | en |
dc.relation.ispartofseries | 293 | en |
dc.relation.ispartofseries | 1-2 | en |
dc.rights | Y | en |
dc.subject | Neuroscience | en |
dc.subject | Multiple sclerosis | en |
dc.title | Impaired information processing speed and attention allocation in multiple sclerosis patients versus controls: A high-density EEG study | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/reillyri | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/whelanr3 | en |
dc.identifier.rssinternalid | 67421 | en |
dc.subject.TCDTheme | Neuroscience | en |
dc.subject.TCDTheme | Next Generation Medical Devices | en |
dc.identifier.rssuri | http://dx.doi.org/10.1016/j.jns.2010.03.010 | en |
dc.identifier.orcid_id | 0000-0001-8578-1245 | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |