dc.contributor.author | BOWIE, ANDREW | |
dc.contributor.author | FLANNERY, SINEAD | |
dc.date.accessioned | 2010-11-11T16:10:59Z | |
dc.date.available | 2010-11-11T16:10:59Z | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010 | en |
dc.identifier.citation | Sinead Flannery and Andrew G. Bowie, The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling, Biochemical Pharmacology, 80, 12, 2010, 1981-1991 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/41142 | |
dc.description | PUBLISHED | en |
dc.description.abstract | The interleukin-receptor-associated kinase (IRAK) family are involved in regulating Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways. TLRs are pattern recognition receptors of the innate immune response that are responsible for sensing pathogens and initiating immunity, while IL-1 is one of the key cytokines that mediates inflammation. As such, IL-1/TLR signalling pathways and the IRAK family are critical in anti-pathogen responses, inflammation and autoimmunity. The family comprises of four members, IRAK-1, IRAK-2, IRAK-M (IRAK-3) and IRAK-4, and has a role in both positive and negative regulation of signal transduction. While it was once thought that the family displayed some redundancy, each member of the family is emerging as a distinct and vital contributor to IL-1/TLR signalling mechanisms. Knockout mouse studies have explored the relative contribution of each of the IRAKs in IL-1/TLR signalling, while the recent generation of kinase-inactive knock-in IRAK-4 mice have revealed which of IRAK-4 functions require its kinase activity. IRAK-2, previously thought of as a pseudokinase, has recently been proposed to have kinase activity that is essential for TLR signalling. Not surprisingly given their critical role in IL-1/TLR signalling, the IRAK family members have been implicated in certain disease models including human immunodeficiencies. Thus the potential targeting of these essential protein kinases therapeutically is also discussed. | en |
dc.format.extent | 1981-1991 | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.relation.ispartofseries | Biochemical Pharmacology; | |
dc.relation.ispartofseries | 80; | |
dc.relation.ispartofseries | 12; | |
dc.rights | Y | en |
dc.subject | Immunology | en |
dc.subject | cytokines | en |
dc.subject | Interleukin-1 | en |
dc.title | The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/flannes | |
dc.identifier.peoplefinderurl | http://people.tcd.ie/agbowie | |
dc.identifier.peoplefinderurl | http://people.tcd.ie/flannes | |
dc.identifier.rssinternalid | 67312 | |
dc.identifier.rssuri | http://dx.doi.org/10.1016/j.bcp.2010.06.020 | en |
dc.contributor.sponsor | Science Foundation Ireland | en |